The Trump Administration announced more than $5 billion in federal commitments to expand the Genesis Mission, a cross-agency effort to deploy artificial intelligence across U.S. science and engineering. The program, led by the White House Office of Science and Technology Policy and launched by executive order in 2025, will coordinate over 15 agencies and 278 selected projects, leveraging a Department of Energy-built platform that links researchers to data, compute and AI tools.
New National Science and Technology Challenges target health, energy, infrastructure, manufacturing and national security. Priorities include modeling chronic disease, accelerating pediatric cancer insights, repurposing drugs, and using VA data to improve veterans’ outcomes. Infrastructure and energy initiatives will develop digital twins of assets and modernize the electric grid. Industrial goals span AI-enabled microelectronics R&D, biomanufacturing scale-up and faster weapons-component design. Discovery efforts cover mining decades of NASA space data, autonomous labs, AI-accelerated quantum systems, predictive biology and materials-by-design. Security work includes early detection of biological threats, materials qualification for deterrence and nuclear-forensics attribution.
Officials said the effort aims to “double America’s R&D output” by unifying data assets, high-performance computing and AI methods across government, with further industry, philanthropic and international participation expected. Execution will hinge on secure data access, rigorous scientific standards and rapid technology transition to measurable public benefit.
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